HIGHLIGHTS
- who: Qian Wu from the University of Cambridge, Tennis Court Road, GA Cambridge, UK have published the paper: Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites, in the Journal: (JOURNAL)
- what: BRCA1-BRCT domains bind to proteins containing the serine-proline-x-phenylalanine (pSPxF) motif including Bach1/FancJ and CtIP. this study the authors demonstrate that ionizing radiation (IR)-induces ATM-dependent phosphorylation of serine 404 (S404) next to the pSPxF motif. Crystal structures of BRCT/Abraxas show that phosphorylation of is important for extensive interactions through the . . .
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