Structure of dnmt3b homo-oligomer reveals vulnerability to impairment by icf mutations

HIGHLIGHTS

  • who: Linfeng Gao from the Environmental Toxicology Graduate Program, University of have published the Article: Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
  • what: For the purpose of comparison with the DNMT3B-DNMT3L complex, the authors focus on discussing the tetrameric unit of DNMT3B macro-oligomer in this study. This study reports the structure of DNMT3B homooligomer, which provides a unique opportunity for the field to gain critical insights into the molecular mechanism by which DNMT3B homo-oligomers (e_g macro-oligomer) regulate genome methylation . . .

     

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