HIGHLIGHTS
- who: Endocrinology et al. from the FIRS Laboratories, RSR Ltd, Parc Ty Glas, Llanishen, Cardiff, UK have published the Article: Structure of full-length TSH receptor in complex with antibody K1-70u2122, in the Journal: (JOURNAL)
SUMMARY
TSH and TRAbs bind principally to the concave surface of the receptor`s leucine-rich-repeat domain (LRD, amino_acids 22-279). The crystal_structures of the human TSHR LRD (amino_acids, 22-260; TSHR260) bound to the thyroid-stimulating human monoclonal autoantibody (MAB) M22™ (Sanders et_al 2003) and the blocking type MAB K1-70™ (Evans et_al 2010, Furmaniak . . .
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