HIGHLIGHTS
- who: Hannah R. Bridges from the Medical Research Council Mitochondrial Biology Unit, University ofCambridge , XY, UK have published the research: Structure of inhibitor-bound mammalian complex I, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- how: Density for piericidin was shown pictorially in the structure of Thermus thermophilus complex I6 but neither the model nor data were made available precluding evaluation of the information. The data are consistent with two piericidins binding in the membranebound enzyme assay and with lower occupancy of the distal site in the detergent-solubilised structurally-characterised enzyme.
SUMMARY
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