Structure of the bacillus anthracis sortase a enzyme bound to its sorting signal

HIGHLIGHTS

• who: Albert H. Chan from the (UNIVERSITY) have published the research work: Structure of the Bacillus anthracis Sortase A Enzyme Bound to Its Sorting Signal, in the Journal: (JOURNAL) of October/16,/2015
• what: The authors report NMR studies that show that the appendage in BaSrtA directly contacts the bound sorting signal, potentially increasing the efficiency of sortase-mediated cell wall protein anchoring by retarding the spurious hydrolysis of a key thioacyl reaction intermediate.
• how: The starting conformation of the arginine side chain prior to energy minimization does not affect its positioning in . . .
  

   

  

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