Structure of the complete dimeric human gdap1 core domain provides insights into ligand binding and clustering of disease mutations

HIGHLIGHTS

  • who: Giang Thi Tuyet Nguyen and collaborators from the Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland, Department of have published the paper: Structure of the Complete Dimeric Human GDAP1 Core Domain Provides Insights into Ligand Binding and Clustering of Disease Mutations, in the Journal: (JOURNAL)
  • what: The authors describe the crystal_structure of the complete dimeric GDAP1 core domain, and based on its unique mode of dimerization, the authors propose a model for full-length GDAP1 on the MOM. Contrary to predictions, the authors show that GDAP1 lacks helix . . .

     

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