Structure of the dock2−elmo1 complex provides insights into regulation of the auto-inhibited state

HIGHLIGHTS

• who: Leifu Chang from the MRC Laboratory of Molecular Biology, Cambridge , QH, UKMcGill University have published the research: Structure of the DOCK2−ELMO1 complex provides insights into regulation of the auto-inhibited state, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors aimed to determine if removing ELMO1NTD would facilitate DOCK2-dependent RAC1 binding or activation in cells. The authors propose that this could be regulated by two mechanisms. Because ELMO interacts with numerous additional proteins, such as the membrane protein ClipR-59, required for myoblast fusion61, the model the authors propose here for . . .
  

   

  

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