Structure of the homodimeric androgen receptor ligand-binding domain

HIGHLIGHTS

• who: Marta Nadal from the of Biochemistry and Molecular Biomedicine, Institute of Biomedicine (IBUB) of the University of Barcelona (UB), Barcelona, Spain have published the Article: Structure of the homodimeric androgen receptor ligand-binding domain, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS of 21/06/2016
• what: The authors show that dimerization of AR ligand-binding domain (LBD) is induced by receptor agonists but not by antagonists. The experiments described above were conducted using highly purified, isolated AR-LBD proteins. The authors provide structurefunction insights into how pathogenic mutations that cluster at the dimer interface . . .
  

   

  

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