Structure of the tuberous sclerosis complex 2 (tsc2) n terminus provides insight into complex assembly and tuberous sclerosis pathogenesis*

HIGHLIGHTS

• who: Reinhard Zech from the (UNIVERSITY) have published the research work: Structure of the Tuberous Sclerosis Complex 2 (TSC2) N Terminus Provides Insight into Complex Assembly and Tuberous Sclerosis Pathogenesis*, in the Journal: (JOURNAL) of September/16,/2016
• what: In the efforts to characterize the structure and assembly of the TSC complex, the authors focused on the N terminus of TSC2/ JOURNAL OF BIOLOGICAL CHEMISTRY tuberin, which had been implicated in mediating the interaction with hamartin .
• how: The authors identified basic patches at equivalent positions on TSC2-N and the model of tuberin . . .
  

   

  

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