HIGHLIGHTS
- who: Bojian Ding from the (UNIVERSITY) have published the paper: Structures reveal a key mechanism of WAVE regulatory complex activation by Rac1 GTPase, in the Journal: (JOURNAL) of 23/05/2022
- what: The authors report WRC structures by itself, and when bound to single or double Rac1 molecules, at ~3 u00c5 resolutions by cryogenic-electron microscopy. To test this model, the authors designed three separate mutations to disrupt the tyrosine lock from different angles and then used GST-Rac1 Nature Communications | 13:5444 the A site. Besides providing a structural perspective for several disease mutations . . .
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