Subcortical-cortical dynamical states of the human brain and their breakdown in stroke

HIGHLIGHTS

SUMMARY

    Using functional magnetic_resonance imaging (fMRI) at rest, the authors identify Dynamic Functional States (DFSs), transient but recurrent clusters of cortical and subcortical regions synchronizing at ultraslow frequencies. The authors observe that shifts in cortical clusters are temporally coincident with shifts in subcortical clusters, with cortical regions flexibly synchronizing with either limbic regions (hippocampus/amygdala), or subcortical nuclei (thalamus/basal ganglia). More recently, it has been shown that this network structure reflects the long-time average (‘static FC`) of rapidly switching connectivity patterns (‘dynamic FC` or dFC) which can be consistently observed with different analysis . . .

     

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