HIGHLIGHTS
SUMMARY
For instance, classical fast neutron therapy (FNT), a plausible treatment option for cancers at high risk of local recurrence and radioresistant tumors, has been left behind. Despite some remarkable clinical outcomes achieved at the dawn of FNT in the 1930s, the growing evidence of severe complications affecting normal tissues put the clinical use of neutrons on a long pause. Mixed irradiation with neutrons and photons or gamma rays, featured in several clinical trials, proved as effective as pure neutrons while being remarkably less toxic as compared with the early low-energy neutron units with . . .
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