Subnuclear localisation is associated with gene expression more than parental origin at the imprinted dlk1-dio3 locus

HIGHLIGHTS

SUMMARY

There has been much interest in understanding ways in which the 3D localisation of chromatin can influence or be influenced by gene_expression. Kota and colleagues identified differential localisation of the Gtl2/Meg3 gene in a mouse embryonal stem (ES) cell line with the non-expressed paternal copy being closer to the nuclear periphery than the expressed maternal allele. Although this suggests that the L1 repeat might have an inhibiting effect on local gene_expression via lamina tethering, deletion of the repeat cluster itself did not lead to increased subnuclear localisation associates with activity not repression . . .

 



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