Substrate binding in the mitochondrial adp/atp carrier is a step-wise process guiding the structural changes in the transport cycle

HIGHLIGHTS

• who: Vasiliki Mavridou from the Research Council Mitochondrial Biology Unit, University of have published the Article: Substrate binding in the mitochondrial ADP/ATP carrier is a step-wise process guiding the structural changes in the transport cycle, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors provide the direct experimental identification of the residues involved in substrate binding by combining functional assays with binding studies, using alanine replacement mutants of the substrate translocation pathway (Fig 1).
• how: These data showed that most residues in the translocation pathway are important for efficient ADP . . .
  

   

  

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