HIGHLIGHTS
- who: Stacia Rymarchyk et al. from the Department of Pharmaceutical Sciences, Albany College of Pharmacy and Health Sciences, Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA have published the Article: Substrate-Dependent Sensitivity of SIRT1 to Nicotinamide Inhibition, in the Journal: Biomolecules 2021, 11, 312. of 18/02/2021
- what: The authors report the detailed kinetic analysis of SIRT1-catalyzed reactions using endogenous substrate-based synthetic peptides. The study provides new evidence for "activation by de-repression" as an effective sirtuin activation strategy. This study focuses on one particular human sirtuin isoform, SIRT1 . . .
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