Substrate-induced domain movement in a bifunctional protein, dcpa, regulates cyclic di-gmp turnover: functional implications of a highly conserved motif

HIGHLIGHTS

• who: Binod K. Bharati from the (UNIVERSITY) have published the paper: Substrate-induced domain movement in a bifunctional protein, DcpA, regulates cyclic di-GMP turnover: Functional implications of a highly conserved motif, in the Journal: (JOURNAL) of May/11,/2018
• what: The authors demonstrate that substrate binding in DcpA results in domain movement that prompts a switch from an "open" to a "closed" conformation and alters its catalytic activity. The authors show that a point mutation in the EAL domain of DcpA can affect both the DGC and PDE-A activities significantly. The aim of . . .
  

   

  

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