Substrate induced movement of the metal cofactor between active and resting state

HIGHLIGHTS

• who: Angewandte et al. from the Faculty of Science and Engineering, University of Groningen have published the article: Substrate Induced Movement of the Metal Cofactor between Active and Resting State, in the Journal: (JOURNAL)
• what: The structural characterization of SwHKA revealed a movement of its metal cofactor between two coordination sites of distinct properties, which are interconnected by a dynamic equilibrium.

SUMMARY

Conversely, M2 alternates between two binding_sites to facilitate the sequential activation of the C-1 aldehyde (electron withdrawing effect for reduction at position M2a) and activation of the C . . .

 



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