Substrate recognition mechanism of vamp/synaptobrevin-cleaving clostridial neurotoxins*

HIGHLIGHTS

  • who: Stefan Sikorra from the (UNIVERSITY) have published the article: Substrate Recognition Mechanism of VAMP/Synaptobrevin-cleaving Clostridial Neurotoxins*, in the Journal: (JOURNAL) of July/25,/2008
  • what: The authors report comprehensive information about substrate amino_acids that are essential for VAMP cleavage by BoNT/B, BoNT/D, and TeNT and their role in the catalytic process. This study provides evidence for a conserved recognition strategy of VAMP cleaving CNTs.

SUMMARY

    VOLUME 283. BoNT/A, C, and E cleave SNAP-25 (synaptosome-associated protein of 25 kDa) and SNAP-23 in certain . . .

     

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