Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

HIGHLIGHTS

• who: Aspuria et_al Cancer Metabolism and collaborators from the (UNIVERSITY) have published the article: Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism, in the Journal: (JOURNAL)
• what: Alterations in metabolism have been implicated in cancer, with the main focus on the Warburg effect, a phenomenon in which cancer cells upregulate glycolysis and lactate production while decreasing glucose contribution to the citric acid (TCA) cycle in the mitochondria, even in the presence of sufficient oxygen . The authors investigate whether alterations in SDH function also impact ovarian cancer biology. Knockdown of Sdhb results . . .
  

   

  

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