Superoxide and non-ionotropic signaling in neuronal excitotoxicity

HIGHLIGHTS

  • who: Raymond A. Swanson from the Department of Neurology, University of California, San Francisco, and San Francisco Veterans Affairs Health Care System, San Francisco, CA, United States have published the research work: Superoxide and Non-ionotropic Signaling in Neuronal Excitotoxicity, in the Journal: (JOURNAL)

SUMMARY

    At roughly the same time that nitric oxide was identified as excitotoxic intermediate, studies using electron paramagnetic_resonance and other methods demonstrated that superoxide was likewise produced by neurons during NMDAr stimulation, and that scavenging superoxide could likewise block excitotoxic death (Lafon-Cazal et_al, 1993; Reynolds and Hastings, 1995 . . .

     

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