Superoxide drives progression of parkin/pink1-dependent mitophagy following translocation of parkin to mitochondria

HIGHLIGHTS

• who: Corrected Correction and colleagues from the DepartmentNational University have published the research: Superoxide drives progression of Parkin/PINK1-dependent mitophagy following translocation of Parkin to mitochondria, in the Journal: (JOURNAL)
• what: Since the study showed that superoxide facilitated the execution of mitophagy, the authors investigated if stimulation of mitophagy by ROS was mediated by the activation of the AMPK pathway. Supporting this, the authors show that the regulation of superoxide by SOD mimetic or inhibitor was able to interfere with the progression of Parkin/PINK1-mediated mitophagy. As shown in Figure 6f, the authors . . .
  

   

  

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