Suppression of choroidal neovascularization and fibrosis by a novel rnai therapeutic agent against (pro)renin receptor

HIGHLIGHTS

  • who: Ye Liu from the Department Hokkaido University, Tokyo, Japan have published the article: Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor, in the Journal: (JOURNAL) of 17/09/2019
  • what: The authors investigated the ability of_(P)RR-PshRNA to suppress inflammation-related angiogenesis and fibrosis together with underlying molecular mechanisms using a CNV mouse model, RPE and endothelial cell culture, and human AMD specimens. This study reveals, for the first time, several important findings concerning the involvement of_(P)RR in the pathogenesis of CNV . . .

     

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