Suppression of head and neck cancer cell survival and cisplatin resistance by grp78 small molecule inhibitor yum70

HIGHLIGHTS

• who: Vicky Yamamoto et al. from the Federal University of Rio Grande do Sul, Brazil have published the article: Suppression of head and neck cancer cell survival and cisplatin resistance by GRP78 small molecule inhibitor YUM70, in the Journal: (JOURNAL)
• what: The authors report on the effects of AA147 and YUM70 on HNSCC, with the latter as a potential therapeutic agent to combat cisplatin resistance. The authors focused on targeting GRP78, a key pro-survival component for the UPR and uncover the following interesting findings.
• how: Taking advantage of the discovery of YUM70 . . .
  

   

  

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