Suppression of the hbp function increases pancreatic cancer cell sensitivity to a pan-ras inhibitor

HIGHLIGHTS

• who: Francesca Ricciardiello and collaborators from the Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy have published the paper: Suppression of the HBP Function Increases Pancreatic Cancer Cell Sensitivity to a Pan-RAS Inhibitor, in the Journal: Cells 2021, 10, x FOR PEER REVIEW of /2021/
• what: The authors demonstrate that PDAC cells expressing oncogenic KRAS owing to an increase in the flux become strongly reliant on for both proliferation and survival. The authors show that this dependence may be used to significantly enhance the effect of a specific pan-RAS inhibitor . . .
  

   

  

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