Suppressor of fused-restrained hedgehog signaling in chondrocytes is critical for epiphyseal growth plate maintenance and limb elongation in juvenile mice

HIGHLIGHTS

• who: TYPE and collaborators from the Fourth Military Medical University, China have published the Article: Suppressor of fused-restrained Hedgehog signaling in chondrocytes is critical for epiphyseal growth plate maintenance and limb elongation in juvenile mice, in the Journal: (JOURNAL)
• what: The authors explored the role of chondrocyte-specific Hh signaling in growth plate maintenance during juvenile growth. The authors showed that chondrocyte-specific deletion of Smo in 2-week-old mice led to premature hypertrophic differentiation at P30. The authors utilized genetic approaches to specifically inactivate or activate Hh signaling in growth plate chondrocytes . . .
  

   

  

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