Supramolecular organizing centers at the interface of inflammation and neurodegeneration

HIGHLIGHTS

• who: Petra Susjan-Leite from the National Institute of Biology (NIB), United States have published the article: Supramolecular organizing centers at the interface of inflammation and neurodegeneration, in the Journal: (JOURNAL)
• what: Signal transduction from DAMPactivated PRRs receptors to effector enzymes and transcription factors is orchestrated within supramolecular organizing centers (SMOCs) , whose role in neuroinflammation is the focus of this review. The authors provide a comprehensive review of the structural and functional characteristics of SMOCs that were shown or are presumed to play important roles in mediating various layers of neurotoxicity imposed by protein aggregates . . .
  

   

  

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