HIGHLIGHTS
- who: The Oncologist et al. from the Interuniversity Institute for Biostatistics and statistical Bioinformatics (I-BioStat), Hasselt University, Hasselt, Belgium Dana Farber Cancer Institute, Boston, MA, USA have published the article: Surrogacy Beyond Prognosis: The Importance of “Trial-Level” Surrogacy, in the Journal: (JOURNAL)
- what: The authors explore the following conceptual difficulty: how can the surrogate Causal Links Between the Surrogate and Final Endpoint The first reason is apparent in Fig 1, Panel B, where the treatment has a direct effect on survival, in addition to the indirect effect on survival that is mediated by . . .
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