HIGHLIGHTS
SUMMARY
There, the conidia are embedded in the moist and nutrient-rich surfactant layer covering the alveolar epithelial_cells (AEC), allowing them to swell and germinate within a short period of about six hours7,12. While this process is still poorly understood, several studies suggest that lung epithelial_cells tend to fail acidifying the phagolysosome and by that allow conidia to form hyphae enabling the fungus to disseminate in the body18,19. The SIM is capable of predicting minimal AM numbers that are necessary to reach certain threshold values of infection clearance that are measured by an . . .
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