Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis

HIGHLIGHTS

• who: Sustained androgen receptor signaling and colleagues from the of Biochemistry, University of Lausanne, Epalinges, Switzerland have published the paper: Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis, in the Journal: (JOURNAL) of 19/09/2022
• what: In this study, based on analysis of a large panel of clinical samples and melanoma cells from both male and female patients, the authors show that, irrespective of expression levels, genetic and pharmacological suppression of AR activity triggers melanoma cell senescence and limits tumorigenesis, eliciting a gene_expression signature related to IFN and . . .
  

   

  

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