Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by nutlin-3 in a mouse model of fragile x syndrome

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  • who: Sahar Javadi from the Waisman Center, University of Wisconsin-Madison, Madison, WI, USA have published the research: Sustained correction of hippocampal neurogenic and cognitive deficits after a brief treatment by Nutlin-3 in a mouse model of fragile X syndrome, in the Journal: (JOURNAL)
  • what: The authors investigated whether Nutlin-3 treatment had a sustained impact on neurogenesis and cognitive behaviors of FXS mice. The authors aimed to determine the potential mechanisms underlying the sustained rescue effect by Nutlin-3. The analysis showed that the top TFs are mainly involved in stem_cell fate specification . . .

     

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