Switchable control of scaffold protein activity via engineered phosphoregulated autoinhibition

HIGHLIGHTS

• who: Arjan Hazegh Nikroo et al. from the (UNIVERSITY) have published the article: Switchable Control of Scaffold Protein Activity via Engineered Phosphoregulated Autoinhibition, in the Journal: (JOURNAL) of June/29,/2022
• what: We presented a modular strategy to introduce reversible control over scaffold protein activity.
• how: The authors presented a modular strategy to introduce reversible control over scaffold protein activity.

SUMMARY

By integrating two key signaling mechanisms, scaffold-mediated signaling and phosphorylation, this approach allows for the bidirectional regulation of 14-3-3 scaffolding activity. ■ SCAFFOLD DESIGN AND SYNTHESIS . . .

 



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