HIGHLIGHTS
- who: Kyoko Chiba from the University of USA have published the Article: Synergistic autoinhibition and activation mechanisms control kinesin-1 motor activity, in the Journal: (JOURNAL) of May/31,/2022
- what: The authors show that the KLC inhibits the kinesin-microtubule interaction independently from the proposed intramolecular interaction within KHC.
- how: This result is not consistent with the current models for kinesin autoinhibition proposing that the tail must fold back to allow the IAK domain to bind to the motors and also to place the KLCs in close proximity to the motor domains . . .
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