Synergy of nanodiamond-doxorubicin conjugates and pd-l1 blockade effectively turns tumor-associated macrophages against tumor cells

HIGHLIGHTS

• who: Hua-Zhen Xu from the Department of Pharmacology, School of Basic Medical Sciences, Wuhan University, Donghu No185, Wuhan, China have published the paper: Synergy of nanodiamond-doxorubicin conjugates and PD-L1 blockade effectively turns tumor-associated macrophages against tumor cells, in the Journal: (JOURNAL)
• what: In a separate work on murine breast cancer cells , the authors demonstrate that DOX is distributed both in the nuclei and lysosomes causing both severe DNA damage and endoplasmic_reticulum (ER) stress while NanoDOX mainly stays in the lysosomes where doxorubicin is slowly released, due to acid hydrolysis of the . . .
  

   

  

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