HIGHLIGHTS
- who: Richard J. Epstein et al. from the University of New South Wales, St Vincent`s Hospital Campus, Sydney, Australia, Garvan Institute of have published the article: Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice, in the Journal: PLOS ONE of December/22,/2022
- what: The association between synonymous CpG-variant Trp53 sequences and maldevelopment reported here supports, albeit indirectly, a growing body of epigenetic evidence favoring a CpG phenotype, though it is unclear whether this is due to pre-translational methylationdependent . . .
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