Synthesis and biological evaluation of 5-fluoro-2-oxindole derivatives as potential α -glucosidase inhibitors

HIGHLIGHTS

  • who: -Fluoro- et al. from the School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China have published the Article: Synthesis and Biological Evaluation of 5-Fluoro-2-Oxindole Derivatives as Potential u03b1 -Glucosidase Inhibitors, in the Journal: (JOURNAL)
  • what: A series of u03b1-glucosidase inhibitors based on 5-fluoro-2oxindole have been synthesized and evaluated.
  • how: These results showed that compounds 3d 3f and 3i could bind with the free enzyme as well as the enzyme-substrate complex of u03b1-glucosidase.

SUMMARY

    Diabetes is a chronic metabolic disorder . . .

     

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