Synthesis and characterisation of new antimalarial fluorinated triazolopyrazine compounds

HIGHLIGHTS

  • who: Kah Yean Lum et al. from the Griffith Institute for Drug Discovery, School of Environment and, Griffith University, Nathan, QLD, Australia, School of have published the article: Synthesis and characterisation of new antimalarial fluorinated triazolopyrazine compounds, in the Journal: (JOURNAL)
  • what: Three selected Series 4 triazolopyrazine scaffolds (1-3) were converted to three known (4-6) and three new ether-linked derivatives (7-9).
  • how: The antimalarial data indicated that substitution of H-8 of ether-linked triazolopyrazines with fluoroalkyl moieties led to a reduction or loss of activity at the tested . . .

     

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