HIGHLIGHTS
- who: Kiran S. Toti and colleagues from the Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH have published the paper: Synthesis and Effect of Conformationally Locked Carbocyclic Guanine Nucleotides on Dynamin, in the Journal: Biomolecules 2022, 12, x FOR PEER REVIEW of 16/04/2022
- how: With as a model system the authors examined the effects of_(N)-GTP and_(S)-GTP dynamin-mediated membrane constriction an activity essential for endocytosis. membrane constriction and fission activity are dependent GTP binding and hydrolysis but the effect of the conformational state . . .
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