Synthesis and evaluation of anti-hiv activity of mono- and di-substituted phosphonamidate conjugates of tenofovir

HIGHLIGHTS

  • who: Aaminat Qureshi and collaborators from the Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Sam Higginbottom University of Agriculture, Technology and, Prayagraj, India have published the article: Synthesis and Evaluation of Anti-HIV Activity of Mono- and Di-Substituted Phosphonamidate Conjugates of Tenofovir, in the Journal: Molecules 2022, 27, x FOR PEER REVIEW of /2022/
  • how: The authors hypothesized that the conjugation or combination of the lipophilic amide bond with nucleotide-based tenofovir (TFV) could improve the anti-HIV activity . . .

     

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