Synthesis and exon-skipping properties of a 3′-ursodeoxycholic acid-conjugated oligonucleotide targeting dmd pre-mrna: pre-synthetic versus post-synthetic approach

HIGHLIGHTS

• who: Elena Marchesi and colleagues from the Department of Environmental and Prevention Sciences, University of Ferrara, Ferrara, Italy have published the article: Synthesis and Exon-Skipping Properties of a 3'-Ursodeoxycholic Acid-Conjugated Oligonucleotide Targeting DMD Pre-mRNA: Pre-Synthetic versus Post-Synthetic Approach, in the Journal: Molecules 2021, 26, 7662. of /2021/
• what: The authors report the preparation of a 20-mer 20 -OMe PS oligonucleotide conjugated at 0 3 -end with ursodeoxycholic acid (ASO 51 30 -UDC, Figure 1), involved in the targeting of human DMD exon 51 . Thanks to the well -established . . .
  

   

  

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