Synthesis and kinase inhibitory potencies of pyrazolo[3,4-g]isoquinolines

HIGHLIGHTS

• who: Mathilde Defois and collaborators from the Universitu00e9 Clermont Auvergne, CNRS, Clermont Auvergne INP, ICCF, Clermont-Ferrand, France have published the Article: Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines, in the Journal: Molecules 2022, 27, 5578. of /2022/
• what: We synthesized a series of pyrazolo[3,4-g]isoquinoline derivatives diversely substituted at the 4- or 8-position.
• how: Fortunately the authors identified lead compound I exhibiting a good activity toward Haspin (IC50 Haspin=50 nM) and selectivity (only 12% of kinase inhibited when tested on a large panel . . .
  

   

  

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