Synthesis and preliminary biological evaluation of two fluoroolefin analogs of largazole inspired by the structural similarity of the side chain unit in psammaplin a

HIGHLIGHTS

  • who: Bingbing Zhang and collaborators from the School of Pharmacy, Fudan University, Zhangheng Road, Pudong Zone, Shanghai, China have published the article: Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A, in the Journal: (JOURNAL)
  • what: The authors report our , and furthermore, the replacement of the olefin with fluoroolefin has little influence on thework rigid on synthesis and biological two novel fluoro olefin of Largazole. conformation of preliminary Largazole.
  • how: The inhibitory potencies against human HDACs (Class I . . .

     

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