HIGHLIGHTS
- who: Chi-I Chang and colleagues from the Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung, Taiwan have published the article: Synthesis and Structure-Activity Relationship of Salvinal Derivatives as Potent Microtubule Inhibitors, in the Journal: (JOURNAL) of 17/02/2023
- what: In this study, the depolymerization activity of compounds 4, 19, 20, 25, and 26 on pure MAP-rich tubulins were assessed in_vitro. The authors synthesized a series of salvinal derivatives and evaluated their structure-activity relationship (SAR) in terms of antiproliferation in KB and HONE1 cancer cell . . .
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