Synthesis and structure-activity relationship studies of pyrido [1,2-e]purine-2,4(1h,3h)-dione derivatives targeting flavin-dependent thymidylate synthase in mycobacterium tuberculosis

HIGHLIGHTS

• who: Nicolas G. Biteau et al. from the Institute of Organic and Analytical Chemistry, CNRS UMR, Universitu00e9 d`Orlu00e9ans, Rue de Chartres, , Orleans, France have published the article: Synthesis and Structure-Activity Relationship Studies of Pyrido [1,2-e]Purine-2,4(1H,3H)-Dione Derivatives Targeting Flavin-Dependent Thymidylate Synthase in Mycobacterium tuberculosis, in the Journal: Molecules 2022, 6216 of /2022/
• what: The authors report herein the synthesis and structure-activity relationship of a novel series of hitherto unknown pyrid purine-2 4(1H 3H)-dione analogues. This study aimed at identifying substituents at . . .
  

   

  

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