Synthesis, formulation and characterization of immunotherapeutic glycosylated dendrimer/cgamp complexes for cd206 targeted delivery to m2 macrophages in cold tumors

HIGHLIGHTS

• who: Marija Petrovic et al. from the School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland have published the research work: Synthesis, Formulation and Characterization of Immunotherapeutic Glycosylated Dendrimer/cGAMP Complexes for CD206 Targeted Delivery to M2 Macrophages in Cold Tumors, in the Journal: Pharmaceutics 2022, 1883 of 13/07/2022
• what: As it was shown that eukaryotic cyclic dinucleotide (CDN)-20 30 Cyclic GMP-AMP (20 30 cGAMP)-showed a higher affinity towards the STING pathway compared to prokaryotic 30 30 cGAMP, for the purpose of this work, 20 30 cGAMP was the ligand . . .
  

   

  

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