Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential ras/pi3k/akt/jnk inhibition in breast carcinoma cells

HIGHLIGHTS

• who: Maha M. Salem from the Department Tanta University have published the research: Synthesis, molecular docking, and in-vitro studies of pyrimidine-2-thione derivatives as antineoplastic agents via potential RAS/PI3K/Akt/JNK inhibition in breast carcinoma cells, in the Journal: Scientific Reports Scientific Reports
• what: Pyrimidine-2-thione derivatives 2-6 were successfully synthesized via conventional and ultrasonic irradiation techniques.

SUMMARY

Human breast MCF-7 (#ATCC HTB-22), MDA-MB-231 (#ATCC HTB-26), colorectal Caco-2 (# ATCC HTB-37), and pancreatic (# ATCC CRL-1469) cancer cell lines, as . . .

 



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