Synthesis of 1,3-diyne derivatives of lembehyne b with antitumor and neuritogenic activity “2279

HIGHLIGHTS

SUMMARY

Natural polyacetylenes are compounds containing two or more carbon-carbon triple bonds in their structure. Synthesis Synthesis of of the the new new 1,3-diyne 1,3-diyne derivatives derivatives of of lembehyne lembehyne B. B. (a) (a) EtMgBr, EtMgBr,Mg, Mg,Cp Cp22TiCl TiCl22, Scheme O, rt; rt; (b) (b) H H++;; (c) rt, 85%; 85%; (d) (d) TBAF, TBAF, THF, THF,rt, rt,99%. Synthesis of the new 1,3-diyne derivatives of lembehyne B. (a) EtMgBr, Mg, Cp2TiCl2, Et2O, rt; (b) H+; (c) 1-lithium-4-trimethylsilyl-1,3-butadiine . . .

 



If you want to have access to all the content you need to log in!

Thanks :)

Username or Email

Password

Remember me

Lost your password?

If you don't have an account, you can create one here.