Synthesis of an amphiphilic vancomycin aglycone derivative inspired by polymyxins: overcoming glycopeptide resistance in gram-positive and gram-negative bacteria in synergy with teicoplanin in vitro

HIGHLIGHTS

  • who: Zsolt Szu0171cs from the DepartmentUniversity of have published the article: Synthesis of an amphiphilic vancomycin aglycone derivative inspired by polymyxins: overcoming glycopeptide resistance in Gram-positive and Gram-negative bacteria in synergy with teicoplanin in vitro, in the Journal: Scientific Reports Scientific Reports
  • what: The new polymyxin-like vancomycin aglycone derivative 14 showed remarkable activity against resistant Grampositive bacteria but exerted only moderate activity against non-resistant strains.
  • how: (The NMR data are collected in Tables 1 and 2 atom numbering is shown in Fig 6).

SUMMARY

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