Synthesis of new triazole-based thiosemicarbazone derivatives as anti-alzheimer’s disease candidates: evidence-based in vitro study

HIGHLIGHTS

  • who: Fazal Rahim and colleagues from the Department of Chemistry, Hazara University, Mansehra, Bin Faisal University, Dammam, Saudi Arabia have published the article: Synthesis of New Triazole-Based Thiosemicarbazone Derivatives as Anti-Alzheimeru2019s Disease Candidates: Evidence-Based In Vitro Study, in the Journal: (JOURNAL)
  • what: Triazole-based thiosemicarbazone derivatives (6a-u) were synthesized and screened for potential to inhibit activities of acetylcholinesterase and butyrylcholinesterase enzymes.

SUMMARY

    Alzheimer`s disease (AD) is an irreversible, neurodegenerative and progressive dis1. Inhibition ofofAcetylcholinesterase andand Butyrylcholinesterase Activities All the newly synthesized derivatives triazole-based thiosemicarbazone (6a . . .

     

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