Synthesis of the fungal macrolide berkeleylactone a and its inhibition of microbial biofilm formation

HIGHLIGHTS

  • who: Anja from the (UNIVERSITY) have published the research work: Synthesis of the fungal macrolide berkeleylactone A and its inhibition of microbial biofilm formation, in the Journal: (JOURNAL)
  • what: With antibiotics due to limits in drug penetration and increasing drug tolerance [15,16].

SUMMARY

    A CuCN, (R)-PPO, -40 °C (2 h) to -35 °C (18 h) to 0 °C; (ii) Ac2O, pyridine, DMAP, CH2Cl2, rt, 19 h; (iii) K2OsO42H2O (3 mol %), NMO, acetone/H2O, 0 °C to rt, 28.5 h; (iv) NaIO4/SiO2, CH2Cl2, rt, 1.75 h; (v . . .

     

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