Synucleinopathy in amyotrophic lateral sclerosis: a potential avenue for antisense therapeutics?

HIGHLIGHTS

  • who: Bradley Roberts and colleagues from the The Perron Institute for Neurological and Translational Science, Nedlands, WA, Australia Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University have published the Article: Synucleinopathy in Amyotrophic Lateral Sclerosis: A Potential Avenue for Antisense Therapeutics?, in the Journal: (JOURNAL)
  • what: A recent review noted that this study had difficulty quantifying specific SNCA transcript expression, casting doubt on the significance of the findings . This study provides evidence that αSyn can induce or exacerbate aggregation of known ALS proteins, leading these authors to suggest that suppressing αSyn-mediated protein interaction . . .

     

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